Drugs that inhibit CYP2D6 activity, such as paroxetine and quinidine, might trigger lowered clearance of oxycodone which could lead on to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.ROXICODONE (oxycodone hydrochloride) ®, like all o